2020-07-08WGCNA文章解析

WGCNA

TERThigh 与TERTlow分组方法:

TERT high (TERThigh) and low (TERTlow) cancers To identify telomerase-associated molecular signatures, we first defined two cancer types based on TERT expression:1) patients with high expression of TERT(TERThigh) and 2) patients with low expression of TERT(TERTlow). We excluded ALT cancers because of their small sample size (~ 5% of all samples in TCGA) andunique genomic and transcriptomic features that may confound the analysis. Samples with 2 or more RNA-Seq quantified reads of TERT were defined as TERThigh, while those with less than 2 reads of TERT and without known ALT-related somatic alterations (ATRX or DAXX mutations, deletions or structural variants) were define as TERTlow.

miRNA统计分析方法:

DNAmethylation 

fisher exact test


©著作权归作者所有,转载或内容合作请联系作者
平台声明:文章内容(如有图片或视频亦包括在内)由作者上传并发布,文章内容仅代表作者本人观点,简书系信息发布平台,仅提供信息存储服务。