[]Title: Characterization of striatal dopamine projections across striatal subregions in behavioral flexibility
[]Journal/Year: Eur J Neurosci. (2023)
[]DOI: 10.1111/ejn.15910
[]Key Findings: by training mice to learn a lever-pressing self-stimulation instrumental task, activating the dopaminergic axons in dorsomedial, dorsolateral, and ventral striatum facilitated, impaired and partially impaired reversal learning, respectively.
[]Conclusion: the DA release in the dorsomedial striatum is vital for goal-directed behavior, while its release in dorsolateral striatum goes against goal-directed behavior.
[]Comments: 就结论本身而言，本研究毫无新意，属于用一种新系统去重复一个已知的结论。就实验结果本身而言，也存在诸多矛盾不可解的地方。很多时候，对于搞科研的人而言，就是需要有定力去看很多可能毫无价值的论文。如果没有这份定力，始终只追踪顶尖杂志的论文，也是很难获得具有较高新意的想法的。所以，这里面存在一个悖论：即要想挖掘出别人没有觉察到的宝贝，你就得去翻看很多没人看甚至“没有价值”的材料。所谓“深入浅出”，便是这个道理。一个人学问的功力或许就隐藏在ta读过多少其他人没有读过或者不愿去读的材料？
