"目录号: HY-15337
Hesperidin (HP)是一个生物类黄酮，具有生物和药理属性是一种有效的抗氧化,抗炎,抗癌,与降脂降压代理活动。
相关产品
Cycloheximide-TAK-242-LY294002-3-Methyladenine-(+)-JQ-1-SB 203580-SP600125-U0126-Enzalutamide-Actinomycin D-Olaparib-Doxorubicin hydrochloride-Dorsomorphin dihydrochloride-Mitomycin C-Bortezomib-
生物活性
Description
Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]
Clinical Trial
Purdue University-Nestec Ltd.
Osteoporosis, Postmenopausal
April 2011
University of Rome Tor Vergata
Endothelial Dysfunction-Metabolic Syndrome
November 2008
Phase 2
University of Maryland
Obesity-Insulin Resistance
June 2015
Phase 2
Nestlé-National University of Malaysia
Osteopenia-Osteoporosis
October 2007
Phase 2
Maastricht University Medical Center
Metabolic Syndrome-Obesity
February 2015
Phase 2
SunWave Pharma-Opera Contract Research Organization SRL
Chronic Venous Insufficiency
November 2016
Phase 3
Nestlé-Institut National de la Recherche Agronomique-Centre de Recherche en Nutrition Humaine. Clermont-Ferrand, France
Osteoporosis, Osteopenia
March 2006
Phase 3
Laboratório Teuto Brasileiro S/A
Chronic Venous Insufficiency-Disease
February 2012
Phase 3
View MoreCollapse
References
