The story at beginning with several former classmates gathered in Chicago. Everyone was trying to cope with the unexpected changes that were happening to them in recent years.And most admitted that they did not know a good way to handle them.
Among them , Michael told a story "Who Moved My Cheese". There are four little characters who ran through a maze looking for cheese.
The mice ,Sniff and Scurry, used the simple,trail-and-error method of finding cheese.However , the two Littlepeople , Hem and Haw,had very complex brains with bliefs and emotions.they relied on their more sophisticated methods of finding Cheese.