中科院的周宁一老师,2013年在AEM杂志发表文章(IntragenomicHeterogeneity of 16S rRNA Genes Causes Overestimation of Prokaryotic Diversity),研究比较了16S不同区域的测序结果
Sun D L, Jiang X, Wu Q L, et al. Intragenomic heterogeneity of 16S rRNA genescauses overestimation of prokaryotic diversity. Applied and environmentalmicrobiology, 2013, 79(19): 5962-5969.
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